最近听 The Captive Imagination 这本书，听到作者讲他临床用 ketamine + mindfulness therapy 来治疗可卡因成瘾。他认为成瘾的问题并不在于物质本身或是依赖者的大脑，而是主体对物质形成的一种虚构，以及对这种虚构的迷恋（例如「我的生活没有希望，唯一能给我解脱的是酒精/可卡因」）。在临床治疗中，首先进行 mindfulness therapy 的准备，之后在 ketamine 的致幻作用下，患者有时会经历一种神秘体验。作者认为比起药物的生理影响，这一体验更是改变的关键。书中给出了一名患者的自述：“I kept repeating, I need nothing, I am nothing, my thoughts, my sensations were nothing. But it was a nothing that is also everything.” 之后作者说：”It awakens the person to his fundamental freedom, or allows for communion with the ever-present space, confronts him with the shadow that obscures everything, or unveils the ecstatic mystery within each moment. The experience may take many directions, though there is shared momentum that unites these separate dreams: an unveiling of the ineffable ground in which reality is a mere stratum.” 或许可以说，这种神秘体验意味着脱离被禁锢的想象，回到一种最初的沉默，并从中创造新的叙事；也会令人联想到文学或是宗教或是精神分析的体验（conversion experience, imagination, dream）
